Place the address on the correct side of the boundary
Check whether the proposed home is within Durham city limits. The municipal notice makes that fact central to the permit route. For city property, compare the planned operation with every no-impact condition. For county property, do not assume the same notice creates an equivalent exception.
Describe staff, visitors, parking and visible activity in writing. Keep the description factual. Saying the business is online does not explain whether patients come to the house or employees use it each day. If the facts sit close to a condition, ask planning staff for a determination before relying on the exception.
Save the response with the address and operating description. That record should make clear what you asked and what the answer covered. An approval for a quiet administrative use should not silently become evidence for a later clinic. Make a new premises review part of the decision to change the business.